Allen D A, Stoupis C, Torres G M, Call G A, Litwiller T L, Ros P R
Department of Radiology, Shands Hospital, University of Florida College of Medicine, Gainesville 82610-0374.
Clin Imaging. 1994 Jan-Mar;18(1):72-4. doi: 10.1016/0899-7071(94)90151-1.
A prospective, randomized study was performed to examine the image quality of varying reduced doses of an intravenous (IV) nonionic contrast agent (ioversol, 320 mg/ml organically bound iodine) compared with the quality obtained using the maximum permissible dose (150 ml) of the same agent. Forty-five patients referred for abdominal-pelvic computed tomography (CT) scan were randomized into five groups to receive contrast doses equivalent to 100, 75, 65, 50, or 30% of 150 ml of contrast agent. The images were scored for diagnostic image quality in eight anatomical regions of interest and, in addition, quantitative analysis of density measurements were performed in the abdominal aorta and inferior vena cava. There was no statistically significant difference in either image quality, in any anatomical region, or in vascular density measurements between the group receiving 100% and the group receiving 75% of 150 ml of nonionic contrast agent. Patients receiving 65% and lower doses demonstrated a statistically significant decrease in enhancement, although all scans were diagnostically adequate. This study demonstrates that dynamic abdominal and pelvic CT scans obtained using a reduced dose of nonionic IV contrast agent are equivalent in diagnostic image quality compared with those scans obtained with the higher permissible dose of the same agent.
进行了一项前瞻性随机研究，以检查静脉注射（IV）非离子型造影剂（碘海醇，320mg/ml有机结合碘）不同降低剂量的图像质量，并与使用相同造影剂最大允许剂量（150ml）所获得的图像质量进行比较。将45名因腹部-盆腔计算机断层扫描（CT）而就诊的患者随机分为五组，分别接受相当于150ml造影剂100%、75%、65%、50%或30%的造影剂剂量。对八个感兴趣的解剖区域的图像进行诊断图像质量评分，此外，还对腹主动脉和下腔静脉进行了密度测量的定量分析。接受150ml非离子型造影剂100%剂量的组和接受75%剂量的组之间，在任何解剖区域的图像质量或血管密度测量方面均无统计学显著差异。接受65%及更低剂量的患者增强效果有统计学显著下降，尽管所有扫描在诊断上都是足够的。本研究表明，使用降低剂量的非离子型静脉造影剂进行的动态腹部和盆腔CT扫描与使用相同造影剂更高允许剂量进行的扫描相比，在诊断图像质量上相当。
