Tsurusaki Masakatsu, Sugimoto Koji, Fujii Masahiko, Sugimura Kazuro
Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, JAPAN.
Radiat Med. 2004 Jul-Aug;22(4):239-45.
The purpose of this study was to assess the quantitative effects of contrast material concentration on hepatic parenchymal and vascular enhancement in multiphasic computed tomography (CT), using multi-detector row helical CT.
We designed a prospective randomized study to test two different concentrations of contrast material on five phasic scans of the liver. One hundred patients were randomly assigned to two groups: an iodine concentration of 300 mg/mL in group A and 370 mg/mL in group B. All patients received a fixed volume of 100 mL at a 4 mL/sec injection rate. Enhancement values for the hepatic parenchyma and aorta at three levels (upper, middle, and lower level of the liver), and values for portal and hepatic veins were statistically compared between the two groups.
Hepatic parenchymal enhancement values at all levels of the liver in portal phase (PP) and equilibrium phase (EP) were significantly higher in group B than in group A (p<0.01). Aortic enhancement values at two levels of the liver (middle and lower) in early hepatic arterial phase (EAP) were significantly higher in group B than in group A (p<0.05), however, there was no significant difference between groups A and B in aortic enhancement during the delayed hepatic arterial phase (DAP). Portal and hepatic venous enhancement values in PP and EP were significantly higher in group B than in group A (p<0.01).
On multiphasic dynamic CT, the use of a higher iodine concentration of contrast material results in higher hepatic parenchymal enhancement and aortic enhancement, as well as higher portal and hepatic venous enhancement.
本研究旨在使用多排螺旋CT评估对比剂浓度对多期计算机断层扫描（CT）中肝脏实质和血管强化的定量影响。
我们设计了一项前瞻性随机研究，在肝脏的五期扫描中测试两种不同浓度的对比剂。100例患者被随机分为两组：A组碘浓度为300mg/mL，B组为370mg/mL。所有患者均以4mL/秒的注射速率接受100mL的固定剂量。对两组肝脏三个层面（肝上部、中部和下部）的肝实质和主动脉强化值以及门静脉和肝静脉的值进行统计学比较。
B组门静脉期（PP）和平衡期（EP）肝脏各层面的肝实质强化值均显著高于A组（p<0.01）。在肝动脉早期（EAP），B组肝脏两个层面（中部和下部）的主动脉强化值显著高于A组（p<0.05），然而，在肝动脉延迟期（DAP），A组和B组之间的主动脉强化无显著差异。B组PP和EP期门静脉和肝静脉强化值显著高于A组（p<0.01）。
在多期动态CT上，使用较高碘浓度的对比剂会导致更高的肝实质强化、主动脉强化以及门静脉和肝静脉强化。
