Perry J R, Bril V
Neuromuscular Laboratory, Toronto Hospital, Ontario, Canada.
Can J Neurol Sci. 1994 Feb;21(1):34-7. doi: 10.1017/s0317167100048733.
We compare complications from 66 sural nerve biopsies in 41 patients with diabetic peripheral neuropathy to 40 patients with neuropathy from other causes, using a retrospective telephone survey. Diabetic patients were followed for a mean of 6.8 years and non-diabetics for 5.6 years. Mild long-term pain was described by 18.9% of patients overall with no difference between groups. Mild persistent sensory symptoms, insufficient to interfere with daily activity or warrant medical therapy, were reported by 63.6% of diabetic and 27.5% of non-diabetic patients (p < 0.006). Wound infection and severe pain were uncommon in both groups and no different in diabetics. Significant complications of sural nerve biopsy occurred no more frequently in diabetic than in non-diabetic patients. While sural nerve biopsy plays no role in the routine evaluation of diabetic peripheral neuropathy, it may be performed without increased risk when indicated in these patients to exclude other causes of neuropathy and in the context of research trials.
我们采用回顾性电话调查，将41例糖尿病性周围神经病患者的66例腓肠神经活检并发症与40例其他病因所致神经病患者的并发症进行比较。糖尿病患者的随访时间平均为6.8年，非糖尿病患者为5.6年。总体上，18.9%的患者有轻度长期疼痛，两组之间无差异。63.6%的糖尿病患者和27.5%的非糖尿病患者报告有轻度持续性感觉症状，症状程度不足以干扰日常活动或需要药物治疗（p<0.006）。两组伤口感染和严重疼痛均不常见，糖尿病患者与非糖尿病患者无差异。腓肠神经活检的严重并发症在糖尿病患者中发生频率并不高于非糖尿病患者。虽然腓肠神经活检在糖尿病性周围神经病的常规评估中不起作用，但在这些患者中，当为排除其他神经病病因或在研究试验背景下有指征时，进行该活检并不会增加风险。
