Konstadoulakis M M, Ricaniadis N, Driscoll D L, Karakousis C P
Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263.
Eur J Surg Oncol. 1994 Apr;20(2):141-5.
Among 2,500 patients with malignant melanoma treated in our Institute since 1975, 25 patients were treated for melanoma of the female genital system. The sites of involvement were the vulva (11 patients), the vagina (13 patients) and the ovaries (one patient). The surgical treatment comprised radical vulvectomy (seven patients), vaginectomy (five patients) and wide local excision (11 patients). One of two patients with distant metastases at diagnosis received no local treatment. The patient with the ovarian melanoma was treated initially with salpingoophorectomy. The overall estimated 5-year survival rate was 64%. There was no statistical difference between the two primary modes of surgical treatment (radical vs local) in the survival of the patients (estimated 5-year survival = 73% and 67%, respectively), but patients receiving the radical treatment had thicker lesions. Malignant melanoma of the female genital tract, despite earlier reports, is apparently curable in the majority of patients and with increased awareness of this condition and earlier diagnosis, the results may further improve in the future.
自1975年以来，在我院接受治疗的2500例恶性黑色素瘤患者中，有25例为女性生殖系统黑色素瘤。受累部位为外阴（11例）、阴道（13例）和卵巢（1例）。手术治疗包括根治性外阴切除术（7例）、阴道切除术（5例）和广泛局部切除术（11例）。诊断时伴有远处转移的2例患者中有1例未接受局部治疗。卵巢黑色素瘤患者最初接受了输卵管卵巢切除术。总体估计5年生存率为64%。两种主要手术治疗方式（根治性与局部性）在患者生存率方面无统计学差异（估计5年生存率分别为73%和67%），但接受根治性治疗的患者病变较厚。尽管早期有报道，但女性生殖道恶性黑色素瘤显然在大多数患者中是可治愈的，随着对这种疾病认识的提高和早期诊断，未来结果可能会进一步改善。
