Maggino T, Gadducci A, Romagnolo C, Fanucchi A, Fioretti P
Gynaecologic Institute, University of Padua, Italy.
Eur J Surg Oncol. 1994 Apr;20(2):146-50.
In the present work the Authors analyse the role and significance of second-look laparotomy in the management of epithelial ovarian cancer. Eighty-three patients with advanced epithelial ovarian cancer (stage III-IV) followed at the Institutes of Gynecology of Padua and Pisa Universities underwent a negative second-look at a median time of 6 months after first surgery. The incidence of relapse after the negative second-look was 45.8% and the mean time of relapse was 27.4 months. Advanced surgical-pathological stage, the presence of residual disease > 2 cm and serous histotype are risk factors for relapse after a negative second-look. These data confirm that, because of its poor prognostic value, a negative second-look laparotomy should not influence the choice of second line chemotherapy and, consequently is no longer routinely performed in our Institutes.
在本研究中，作者分析了二次剖腹探查术在上皮性卵巢癌治疗中的作用和意义。帕多瓦大学和比萨大学妇科研究所随访的83例晚期上皮性卵巢癌（Ⅲ - Ⅳ期）患者在首次手术后中位时间6个月时进行了阴性二次探查。阴性二次探查后复发率为45.8%，平均复发时间为27.4个月。手术病理分期晚、残留病灶>2 cm以及浆液性组织学类型是阴性二次探查后复发的危险因素。这些数据证实，由于其预后价值不佳，阴性二次剖腹探查术不应影响二线化疗的选择，因此在我们研究所不再常规进行。
