Heliö H, Karaharju E, Böhling T, Nordling S
Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, Finland.
Eur J Surg Oncol. 1994 Jun;20(3):200-6.
The variable clinical course and locally aggressive growth of giant cell tumours of bone cause problems in planning treatment. Curettage and bone grafting is the commonest form of surgical treatment, but recurrence rates as high as 40 per cent have been reported. Thirty-four patients with a GCT were treated in our clinic between years 1982 and 1990. There were three gr 1, 24 gr II and 7 grade III tumours. Operative treatment was carried out in 31. DNA flow cytometry was performed from the sample in 28 patients. The type of treatment played an important role in tumour prognosis: there were 10 recurrences after 18 intralesional procedures, but only one recurrence after tumour resection. DNA flow cytometry was not helpful in predicting tumour behaviour.
骨巨细胞瘤多变的临床病程和局部侵袭性生长给治疗方案的制定带来了难题。刮除术和骨移植是最常见的外科治疗方式，但据报道复发率高达40%。1982年至1990年间，我们诊所共治疗了34例骨巨细胞瘤患者。其中有3例1级、24例2级和7例3级肿瘤。31例患者接受了手术治疗。28例患者的样本进行了DNA流式细胞术检测。治疗方式在肿瘤预后中起着重要作用：18例病损内手术术后有10例复发，但肿瘤切除术后仅有1例复发。DNA流式细胞术对预测肿瘤行为并无帮助。
