Ploski R, Undlien D E, Vinje O, Førre O, Thorsby E, Rønningen K S
Institute of Transplantation Immunology, National Hospital, Oslo, Norway.
Hum Immunol. 1994 Jan;39(1):54-60. doi: 10.1016/0198-8859(94)90101-5.
The TAP1 and TAP2 genes encode a peptide transporter supplying peptides for binding to HLA class I molecules. Both genes are located in the class II region of the HLA complex and are polymorphic. Here we report the distribution of TAP alleles in a group of 285 JRA patients (including various subsets), 165 random controls, and 82 DR8-positive controls. We found a pronounced increase of TAP1B and TAP2C/D in patients, compared with controls. The difference was, however, mainly secondary to a strong linkage disequilibrium between these TAP alleles and DR8, which is significantly increased in JRA. When we compared patients and controls after stratification for DR8 the differences decreased, although an increase of TAP1B in DR8-negative patients remained significant. We conclude that a primary association of JRA with given TAP allels cannot explain the HLA class II associations in JRA. However, we cannot exclude the possibility that TAP1B acts as an additive susceptibility factor in JRA.
TAP1和TAP2基因编码一种肽转运体，为与HLA I类分子结合提供肽段。这两个基因都位于HLA复合体的II类区域，且具有多态性。在此我们报告了TAP等位基因在285例幼年类风湿性关节炎（JRA）患者（包括各种亚型）、165例随机对照以及82例DR8阳性对照中的分布情况。我们发现，与对照相比，患者中TAP1B和TAP2C/D明显增多。然而，这种差异主要是由于这些TAP等位基因与DR8之间存在强烈的连锁不平衡，而DR8在JRA中显著增加。当我们根据DR8进行分层后比较患者和对照时，差异有所减小，尽管DR8阴性患者中TAP1B的增加仍然显著。我们得出结论，JRA与特定TAP等位基因的原发性关联无法解释JRA中HLA II类关联。然而，我们不能排除TAP1B在JRA中作为一个附加易感性因素的可能性。
