Sato Y, Iwata S, Akita H, Kobayashi M, Yokota T, Sunakawa K
Department of Pediatrics, General Ota Hospital.
Jpn J Antibiot. 1994 Mar;47(3):272-9.
Pharmacokinetic, bacteriological and clinical studies on intravenous fluconazole (FLCZ) in deep seated mycoses were performed involving 4 pediatric patients. Clinical and bacteriological assessments were made on 4 patients; clinical improvements were good in 3 patients and bacteriological efficacies were rated as "eradicated" in 3 patients. No side effects nor abnormal laboratory values were observed. The pharmacokinetics were investigated in 2 patients. Good serum FLCZ concentrations were obtained at an intravenous dose of 3-6 mg/kg daily. These results indicate that FLCZ is a useful drug in the treatment of pediatric patients with systemic deep-seated mycosis.
对4名儿科患者进行了静脉注射氟康唑（FLCZ）治疗深部真菌病的药代动力学、细菌学和临床研究。对4名患者进行了临床和细菌学评估；3名患者临床改善良好，3名患者细菌学疗效评定为“根除”。未观察到副作用和实验室值异常。对2名患者进行了药代动力学研究。每日静脉注射剂量为3-6mg/kg时，血清FLCZ浓度良好。这些结果表明，FLCZ是治疗小儿系统性深部真菌病的有效药物。
