[Role of hematopoiesis-inducing microenvironment in the regulation of hematopoiesis during myelosuppression of various origin].

The paper discusses the mechanisms of hemopoiesis regulation on the models of bone marrow hypoplasia induced by cyclophosphane, adriamycin, sublethal and lethal X-ray radiation followed by bone marrow transplantation. The findings suggest that there is the unique complexly organized system of local hemopoiesis regulation in the body (cell elements of the hemopoiesis-inducing microenvironment and their produced humoral factors) whose functional activity increases naturally under the action of different myelotoxic agents. The specific features of hemopoiesis-inducing microenvironmental functioning are largely determined by the extent and specificity of the damaging action of an agent on some individual components of the local regulation regulatory system.