Mel'nikova T S
Patol Fiziol Eksp Ter. 1993 Jul-Dec(4):19-21.
The thresholds of pain and non-pain responses to single electric pulses whose duration was 0.1, 1, 10, 100, and 1000 msec were comparatively analysed in healthy individuals and patients suffering from endogenous affective disorders with bi- and monopolar courses during the development of a depressive phase and after its arrest. An analysis of the mean and modal values of non-pain response thresholds revealed no significant differences in patients and healthy individuals during marked depressive disorders and only after antidepressive therapy there was a tendency to increase non-pain response thresholds. During the development of depression, the thresholds of pain responses to short test signals (0.1 and 1 msec) were significantly lower in patients than in healthy subjects. After cessation of the depressive sympathology there was an increase in pain response thresholds and their approach to those in the healthy examinees, but in the intermission there was a profound rise in pain response thresholds in patients with a bipolar course.
在抑郁期发展过程中及抑郁期结束后，对健康个体以及患有双相和单相病程的内源性情感障碍患者，比较分析了对持续时间为0.1、1、10、100和1000毫秒的单个电脉冲的疼痛和非疼痛反应阈值。对非疼痛反应阈值的均值和众数分析显示，在明显的抑郁障碍期间，患者和健康个体之间没有显著差异，只有在抗抑郁治疗后，非疼痛反应阈值才有升高的趋势。在抑郁症发展过程中，患者对短测试信号（0.1和1毫秒）的疼痛反应阈值明显低于健康受试者。抑郁症状停止后，疼痛反应阈值升高，且接近健康受试者的阈值，但在间歇期，双相病程患者的疼痛反应阈值大幅上升。
