Guarini G
Recenti Prog Med. 1994 Jan;85(1):32-6.
Even today the problem of aging is not well known. The latest discoveries on the arrow of time, the theory of complexity, the identification of dissipative stationary structures in "non equilibrium", the observation that deterministic systems with a complex structure may produce chaos (which today we have begun to identify, with evident contradictions, laws and principles: the laws of disorder), are the new laws by which it will be possible to understand the evolution along the time of automatic control feed-back of homeostasis and so the progression of senescence. The attention is pointed particularly to three magnitudes of modern physics: dynamic stability, dissipative structures and entropy. In aging the structures of automatic control systems are submitted to a greater functional effort with the results of a reduction of dynamic stability, an increase in dissipative phenomena and entropy. Moreover the functional exhaustion of homeostatic systems (the linearization of the system) is not compatible with life unless a substitute system takes on its function. In this condition the possibility of survival of the living subjects is conditioned to the capacity of the vicarial system of having a higher state of "non equilibrium" at disposal and therefore of a higher dissipative capacity. From the valuation of dynamic stability, dissipative structures and entropy, it appears possible in a near future to clarify many aspects of the nature and dynamics of aging.
即使在今天，衰老问题仍未被充分了解。关于时间箭头、复杂性理论、“非平衡态”中耗散稳态结构的识别、具有复杂结构的确定性系统可能产生混沌的观察（如今我们已开始以明显矛盾的方式识别相关规律和原理：无序定律）等最新发现，是有望理解体内平衡自动控制反馈随时间的演变以及衰老进程的新规律。特别值得关注的是现代物理学的三个量：动态稳定性、耗散结构和熵。在衰老过程中，自动控制系统的结构承受着更大的功能负荷，结果是动态稳定性降低、耗散现象和熵增加。此外，体内平衡系统的功能衰竭（系统的线性化）与生命不相容，除非有替代系统承担其功能。在这种情况下，生物主体的生存可能性取决于替代系统拥有更高“非平衡态”水平从而具有更高耗散能力的程度。从对动态稳定性、耗散结构和熵的评估来看，在不久的将来似乎有可能阐明衰老的本质和动态的许多方面。
