Wadström J, Tengblad A
Department of Transplantation Surgery, University Hospital, Uppsala, Sweden.
Ups J Med Sci. 1993;98(2):159-67. doi: 10.3109/03009739309179309.
Sodium hyaluronate (HA) is known to modulate wound healing and interact with inflammatory reactions. High concentrations of extracellular HA are for example correlated to scarless wound healing. Topical treatment with HA has, however, limited effect due to the rapid clearance of HA in the tissue. In an effort to prolong the dissolution rate and enhance the effect of topically administered HA, HA was incorporated in a cross linked fibrin clot and placed in NaCl. The concentration of HA in the NaCl solution was analysed after 30', 60', 4h, 8h, and 24h. It was found that the dissolution rate of HA incorporated in cross linked fibrin was dramatically decreased in vitro, especially when the HA-fibrin mixture was put at rest and not exposed to a mechanical stress. The findings indicate a new possibility for slow release of HA after topical administration.
透明质酸钠（HA）已知可调节伤口愈合并与炎症反应相互作用。例如，高浓度的细胞外HA与无瘢痕伤口愈合相关。然而，由于HA在组织中的快速清除，HA的局部治疗效果有限。为了延长溶解速率并增强局部施用HA的效果，将HA掺入交联纤维蛋白凝块中并置于氯化钠中。在30分钟、60分钟、4小时、8小时和24小时后分析氯化钠溶液中HA的浓度。发现在体外，掺入交联纤维蛋白中的HA的溶解速率显著降低，特别是当HA-纤维蛋白混合物静置且未受到机械应力时。这些发现表明局部给药后HA缓释的新可能性。
