Dienstbier Z, Hermanská Z, Zámecník J, Melínová L, Skala E, Vacková B
I. interní klinika 1. LF UK, Praha.
Vnitr Lek. 1994 Mar;40(3):163-6.
The authors describe data on the course of pregnancy, delivery and subsequent development of 20 children born to parents treated for Hodgkin's disease. Thirteen women in the clinical stage II and III were delivered of 16 infants (10 daughters and 6 sons) and three men (II A and III A) had four daughters. The parents were in one case treated by irradiation only, twice by chemotherapy only and thirteen times by a combination of irradiation and chemotherapy (COPP/ABVD). The gestation period, parameters of the infants at delivery and the subsequent physical and mental development are normal. In one instance (a girl, now ten and a half years old) the child was born with malformations of the extremities; according to the geneticist this is not related to the previous treatment of the mother. The second child (a son) of this mother is normal. The authors are of the opinion and apply it in the therapeutic protocol in patients of fertile age and do not irradiate nodes in the pelvic region. In treated patients they allow pregnancy only after three or preferably five years following terminated treatment. Survival of patients in the whole group (269 subjects) regardless of age and clinical stage is 75%. The authors are processing a data base of Hodgkin patients since 1968.
作者描述了20名父母曾接受霍奇金病治疗的儿童的妊娠过程、分娩情况及后续发育的数据。处于临床II期和III期的13名女性分娩了16名婴儿（10名女孩和6名男孩），3名男性（II A期和III A期）育有4名女儿。父母中1例仅接受放疗，2例仅接受化疗，13例接受放疗与化疗联合治疗（COPP/ABVD）。妊娠期、婴儿出生时的参数以及随后的身心发育均正常。有1例（一名女孩，现10岁半）出生时伴有肢体畸形；据遗传学家称，这与母亲先前的治疗无关。这位母亲的第二个孩子（一名男孩）发育正常。作者持有这种观点并将其应用于育龄患者的治疗方案中，不对盆腔区域的淋巴结进行放疗。对于接受过治疗的患者，他们仅允许在治疗结束三年后，最好是五年后怀孕。整个组（269名受试者）的患者生存率，无论年龄和临床分期如何，均为75%。自1968年以来，作者一直在处理霍奇金病患者的数据库。
