Coulthard P, Rood J P
Department of Oral and Maxillo-Facial Surgery, University Dental Hospital, Manchester, England.
Anesth Prog. 1993;40(2):35-7.
The effect of midazolam sedation on late evoked potentials (EPs) elicited from painful stimulation of the median nerve was investigated in 20 human volunteers. EPs were recorded from the contralateral scalp at baseline and at 5, 30, and 60 min post-midazolam infusion. Relative amplitudes of the late EPs were significantly reduced after intravenous midazolam infusion and did not return to normal during the 60 min of the experiment. Given the correlation between EP amplitude and subjective reports of experimental pain, the data support the suggestion that midazolam may have some analgesic effect.
在20名人类志愿者中研究了咪达唑仑镇静对正中神经疼痛刺激诱发的晚期诱发电位（EPs）的影响。在基线时以及咪达唑仑输注后5、30和60分钟，从对侧头皮记录EPs。静脉输注咪达唑仑后，晚期EPs的相对振幅显著降低，并且在实验的60分钟内未恢复正常。鉴于EP振幅与实验性疼痛的主观报告之间的相关性，这些数据支持咪达唑仑可能具有某种镇痛作用的观点。
