CD70是CD27的人类配体。

CD70 represents the human ligand for CD27.

作者信息

Hintzen R Q, Lens S M, Koopman G, Pals S T, Spits H, van Lier R A

机构信息

Department of Clinical (Viro-) Immunology, Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam.

出版信息

Int Immunol. 1994 Mar;6(3):477-80. doi: 10.1093/intimm/6.3.477.

DOI:10.1093/intimm/6.3.477

PMID:8186199

Abstract

The recently identified CD27 ligand (L) is a type II transmembrane molecule with significant structural homology to tumor necrosis factor (TNF)-alpha, TNF-beta, lymphotoxin beta, CD40L, and CD30L. Using a CD27L specific mAb we examined the tissue distribution of the molecule, and found its expression to be restricted to B cells in occasional germinal centers, stromal cells in the thymic medulla, and scattered T cells in tonsils, skin and gut. As the limited expression of CD27L closely resembled the reported distribution of the activation antigen CD70, we tested whether CD70 represents the human CD27L. CD70 mAb were found to react with CD27L-expressing transfected mouse fibroblasts. Moreover a number of CD70 mAb could specifically interfere with the cellular binding of CD27L mAb. Thus, CD70 is identical to the human CD27L.

摘要

最近鉴定出的CD27配体（L）是一种II型跨膜分子，与肿瘤坏死因子（TNF）-α、TNF-β、淋巴毒素β、CD40L和CD30L具有显著的结构同源性。我们使用一种CD27L特异性单克隆抗体检测了该分子的组织分布，发现其表达仅限于偶尔生发中心的B细胞、胸腺髓质的基质细胞以及扁桃体、皮肤和肠道中散在的T细胞。由于CD27L的有限表达与报道的激活抗原CD70的分布非常相似，我们测试了CD70是否代表人类CD27L。发现CD70单克隆抗体与表达CD27L的转染小鼠成纤维细胞发生反应。此外，一些CD70单克隆抗体可以特异性干扰CD27L单克隆抗体的细胞结合。因此，CD70与人类CD27L相同。