Seidman L J, Yurgelun-Todd D, Kremen W S, Woods B T, Goldstein J M, Faraone S V, Tsuang M T
Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Boston.
Biol Psychiatry. 1994 Feb 15;35(4):235-46. doi: 10.1016/0006-3223(94)91254-8.
This preliminary study focused on the relationship between prefrontal and temporal lobe MRI measures and neuropsychological performance in chronic schizophrenia. Seventeen schizophrenic inpatients received an MRI and a neuropsychological test battery after clinical stabilization, on average 2 months after admission. The central finding was a significant inverse correlation between neurocognitive measures of prefrontal function and dorsolateral prefrontal cortex (DLPFC) area, strongest in the left hemisphere. Neurocognitive performance did not correlate significantly with orbital frontal area or total temporal lobe volume. The correlations of neuropsychological performance with total frontal volume and whole brain volume were generally not significant, although the pattern was similar to that associated with the DLPFC. Because a number of executive-attention and abstraction measures were significantly associated with the DLPFC, dysfunctions of this region may underlie a syndrome of cognitive dysfunctions. Long-term memory functions were also significantly correlated with the DLPFC, raising the possibility that recall memory defects in schizophrenia are, in part, associated with prefrontal contributions of attention, abstract reasoning, and executive function. This study needs replication with a larger sample of patients and more comprehensive volumetric morphometric analyses.
这项初步研究聚焦于慢性精神分裂症患者前额叶和颞叶的磁共振成像（MRI）测量值与神经心理表现之间的关系。17名精神分裂症住院患者在临床病情稳定后接受了MRI检查和一套神经心理测试，平均在入院后2个月进行。核心发现是前额叶功能的神经认知测量值与背外侧前额叶皮质（DLPFC）面积之间存在显著的负相关，在左半球最为明显。神经认知表现与眶额面积或颞叶总体积无显著相关性。神经心理表现与额叶总体积和全脑体积的相关性通常不显著，尽管其模式与DLPFC相关的模式相似。由于一些执行性注意力和抽象能力测量值与DLPFC显著相关，该区域的功能障碍可能是认知功能障碍综合征的基础。长期记忆功能也与DLPFC显著相关，这增加了精神分裂症患者回忆记忆缺陷部分与前额叶在注意力、抽象推理和执行功能方面的作用相关的可能性。这项研究需要在更大样本的患者中重复进行，并进行更全面的体积形态计量分析。
