Simon B, Schütz E, Müller P, Dixon J S
Kreiskrankenhaus Schwetzingen, Abteilung Gastroenterologie, Germany.
Aliment Pharmacol Ther. 1994 Feb;8(1):135-7. doi: 10.1111/j.1365-2036.1994.tb00171.x.
One hundred and twenty-five patients with duodenal ulcer disease were given continuous ranitidine therapy after initial acute healing. Cumulative remission rates indicated that 95% of patients were ulcer-free after 1 year, 89% at 2 years, 81% at 3 years, 70% at 4 years and 60% at 5 and 6 years. Nine patients had a second recurrence after healing of the first. No patient developed an ulcer complication. These results support the view that long-term continuous ranitidine therapy prevents ulcer recurrence and complications.
125例十二指肠溃疡患者在初始急性愈合后接受雷尼替丁持续治疗。累积缓解率表明，1年后95%的患者溃疡愈合，2年后为89%，3年后为81%，4年后为70%，5年和6年后为60%。9例患者在首次愈合后出现第二次复发。无患者发生溃疡并发症。这些结果支持长期持续使用雷尼替丁治疗可预防溃疡复发和并发症这一观点。
