Fenn G C
Medical Department, Searle, High Wycombe, UK.
Aliment Pharmacol Ther. 1994 Feb;8(1):15-26. doi: 10.1111/j.1365-2036.1994.tb00156.x.
This article reviews various issues surrounding NSAID-induced gastroduodenal ulceration, about which there appear to be conflicting views and data in the literature. These issues include the size, clinical relevance and main site of the problem; when complications occur (early or late?); the relevance of non-ulcer lesions and whether adaptation is a clinically relevant phenomenon.
A comprehensive literature search was carried out to identify relevant new data published since 1987.
NSAIDs are causally associated with more gastric than duodenal ulcers but their use may be associated with duodenal ulcers or complications. Erosive lesions may progress to more severe damage. The theories of early or late onset of complications during a course of NSAID therapy may not be mutually exclusive.
Available data indicate that NSAID ulcers are at least as dangerous as classic peptic ulcers, and result in significant morbidity and mortality which in the patient population does not appear to be significantly reduced by processes such as adaptation.
本文回顾了与非甾体抗炎药（NSAID）引起的胃十二指肠溃疡相关的各种问题，关于这些问题，文献中似乎存在相互矛盾的观点和数据。这些问题包括问题的规模、临床相关性和主要部位；并发症何时发生（早期还是晚期？）；非溃疡性病变的相关性以及适应性是否是一种具有临床意义的现象。
进行了全面的文献检索，以识别自1987年以来发表的相关新数据。
NSAID与胃溃疡的因果关系比十二指肠溃疡更为密切，但它们的使用可能与十二指肠溃疡或并发症有关。糜烂性病变可能会发展为更严重的损伤。NSAID治疗过程中并发症早期或晚期发作的理论可能并非相互排斥。
现有数据表明，NSAID溃疡至少与经典消化性溃疡一样危险，并导致显著的发病率和死亡率，而在患者群体中，适应性等过程似乎并未显著降低这种情况。
