Machado Mayuri A, Velásquez Chamochumbi H
Servicio de Gastroenterología, Hospital Edgardo Rebagliati Martins, IPSS, Lima Peru.
Rev Gastroenterol Peru. 1993;13(3):168-72.
In 46 patients with biliary tract and pancreatic disorders, in which a diagnostic ERCP was performed, we used as premedication Propinoxate or hyoscine N-butyl bromide in a randomised, prospective study to demonstrate their effectiveness. This was achieved through the endoscopic evaluation, to determine the number of duodenal contractions observed 5 to 10 minutes after i.v. administration of the drugs, as well as the grade of distensibility of the intestinal folds and the occurrence or not of adverse reactions such as increased heart rate and hypertension. 25 patients received 20 mgs of hyoscine N-butyl bromide and the rest 5 mgs propinoxate, i.v. plus diazepam. 48% of patients in the first group and 42.9% in the second one, experienced optimum contractions (0 to 1) after 5 minutes; while after 10 minutes this difference was not significant (40% vs 38%). The incidence of adverse reactions, mainly increased heart rate, was higher for the first group (Hyoscine). Thirty minutes after there were not adverse reactions. We believe that propinoxate (PLIDAN) and hyoscine N-butylbromide, can be used in the pre-medication when performing ERCP.
在46例接受诊断性内镜逆行胰胆管造影（ERCP）的胆道和胰腺疾病患者中，我们在一项随机前瞻性研究中使用丙哌卡因或丁溴东莨菪碱作为术前用药，以证明其有效性。这是通过内镜评估来实现的，以确定静脉注射药物后5至10分钟观察到的十二指肠收缩次数，以及肠襞的扩张程度和是否出现诸如心率加快和高血压等不良反应。25例患者静脉注射20毫克丁溴东莨菪碱，其余患者静脉注射5毫克丙哌卡因加地西泮。第一组48%的患者和第二组42.9%的患者在5分钟后出现最佳收缩（0至1级）；而10分钟后这种差异不显著（40%对38%）。第一组（东莨菪碱组）不良反应的发生率较高，主要是心率加快。30分钟后未出现不良反应。我们认为，丙哌卡因（普利丹）和丁溴东莨菪碱可用于ERCP术前用药。
