一种新的免疫球蛋白变体：γ3重链病蛋白CHI
A new immunoglobulin variant: gamma3 heavy chain disease protein CHI.
作者信息
Frangione B
出版信息
Proc Natl Acad Sci U S A. 1976 May;73(5):1552-5. doi: 10.1073/pnas.73.5.1552.
Abstract
Protein CHI is a defective human gamma3 heavy chain immunoglobulin with a deletion encompassing a portion of the variable and constant regions. Joining of the two pieces takes place at the beginning of an extra fragment (Fh) in the constant region where repetitive sequences are found, apparently as the result of gene duplications and/or unequal crossover between gamma genes. It is postulated that a 45 nucleotide fragment is the repetitive unit coding for the extra fragment.
摘要
蛋白质CHI是一种有缺陷的人类γ3重链免疫球蛋白，其缺失部分包括可变区和恒定区的一部分。这两部分的连接发生在恒定区一个额外片段（Fh）的起始处，该区域存在重复序列，显然这是γ基因之间基因重复和/或不等交换的结果。据推测，一个45个核苷酸的片段是编码该额外片段的重复单元。
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