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Biochemical and biosynthetic studies of a crystallizable human gamma 1 heavy-chain disease protein.
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引用本文的文献

1
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J Clin Invest. 1988 Oct;82(4):1244-52. doi: 10.1172/JCI113722.
2
Independent expression of the gene coding for the constant domain of immunoglobulin light chain: evidence from sequence analyses of the precursor of the constant region polypeptide.免疫球蛋白轻链恒定区编码基因的独立表达：来自恒定区多肽前体序列分析的证据。
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3157-61. doi: 10.1073/pnas.74.8.3157.
3
Human heavy chain disease protein WIS: implications for the organization of immunoglobulin genes.人类重链病蛋白WIS：对免疫球蛋白基因组织的影响
Proc Natl Acad Sci U S A. 1979 Jan;76(1):452-6. doi: 10.1073/pnas.76.1.452.

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Peptide separation by two-dimensional chromatography and electrophoresis.通过二维色谱法和电泳法进行肽分离。
J Biol Chem. 1959 Nov;234:2897-900.
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CLINICAL AND IMMUNOCHEMICAL STUDIES OF FOUR CASES OF HEAVY (H-GAMMA-2) CHAIN DISEASE.4例重链（H-γ-2）病的临床与免疫化学研究
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HEAVY CHAIN DISEASE- A NEW DISORDER OF SERUM GAMMA-GLOBULINS : REPORT OF THE FIRST CASE.重链病——一种血清γ球蛋白的新病症：首例病例报告。
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EQUILIBRIUM ULTRACENTRIFUGATION OF DILUTE SOLUTIONS.稀溶液的平衡超速离心法
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Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion.凝胶中的抗原-抗体反应。IV. 扩散协调系统中的反应类型。
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A protein sequenator.蛋白质测序仪。
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The gel-filtration behaviour of proteins related to their molecular weights over a wide range.蛋白质的凝胶过滤行为与其在很宽范围内的分子量相关。
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The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳测定分子量的可靠性。
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一种新的免疫球蛋白变体：γ3重链病蛋白CHI

A new immunoglobulin variant: gamma3 heavy chain disease protein CHI.

作者信息

Frangione B

出版信息

Proc Natl Acad Sci U S A. 1976 May;73(5):1552-5. doi: 10.1073/pnas.73.5.1552.

DOI:10.1073/pnas.73.5.1552
PMID:818639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC430335/
Abstract

Protein CHI is a defective human gamma3 heavy chain immunoglobulin with a deletion encompassing a portion of the variable and constant regions. Joining of the two pieces takes place at the beginning of an extra fragment (Fh) in the constant region where repetitive sequences are found, apparently as the result of gene duplications and/or unequal crossover between gamma genes. It is postulated that a 45 nucleotide fragment is the repetitive unit coding for the extra fragment.

摘要

蛋白质CHI是一种有缺陷的人类γ3重链免疫球蛋白，其缺失部分包括可变区和恒定区的一部分。这两部分的连接发生在恒定区一个额外片段（Fh）的起始处，该区域存在重复序列，显然这是γ基因之间基因重复和/或不等交换的结果。据推测，一个45个核苷酸的片段是编码该额外片段的重复单元。