Phuphanich S, Jacobs M, Spiers A
Department of Neurology, University of South Florida College of Medicine, Tampa.
J Neuroimaging. 1994 Apr;4(2):114-6. doi: 10.1111/jon199442114.
A 36-year-old woman underwent removal of a stage II malignant melanoma from the left ankle in 1985. A single brain metastasis to the right frontal lobe was removed in July 1986. Postoperatively, she received 5-fluorouracil, cisplatin, and etoposide (VP-16) in conjunction with radiation therapy. She achieved remission until March 1988, when left hemiparesis occurred suddenly. Computed tomography and magnetic resonance scans revealed multiple brain metastases. She was treated with a combination of 5-fluorouracil, 1,000 mg/m2 in a 24-hour continuous IV infusion for 5 days; interferon-alpha, 10 million units in subcutaneous injection daily for 10 days; and oral cimetidine, 1,200 mg daily for 7 days. This regimen, repeated every 4 to 6 weeks for four cycles, was well tolerated, with complete remission of neurological deficits and resolution of the lesions seen on the brain scans until she died 11 months later of intracranial hemorrhage secondary to severe thrombocytopenia.
一名36岁女性于1985年接受了左踝II期恶性黑色素瘤切除术。1986年7月切除了右额叶的单个脑转移瘤。术后，她接受了5-氟尿嘧啶、顺铂和依托泊苷（VP-16）联合放射治疗。她病情缓解至1988年3月，此时突然出现左侧偏瘫。计算机断层扫描和磁共振扫描显示多发脑转移瘤。她接受了以下联合治疗：5-氟尿嘧啶，1000mg/m²，24小时持续静脉输注，共5天；α-干扰素，1000万单位，皮下注射，每日1次，共10天；西咪替丁，口服，1200mg，每日1次，共7天。该方案每4至6周重复一次，共四个周期，耐受性良好，神经功能缺损完全缓解，脑扫描显示的病变消退，直至11个月后她死于严重血小板减少继发的颅内出血。
