人乳腺癌核仁组织区蛋白的临床病理评估

A clinicopathological evaluation of nucleolar organizer region proteins in human breast carcinoma.

作者信息

Yoshida Y, Okamura T, Yano K, Kodate M, Oyama T, Inutsuka K, Taga S, Ezaki T

机构信息

Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

出版信息

Surg Oncol. 1994 Feb;3(1):53-7. doi: 10.1016/0960-7404(94)90024-8.

DOI:10.1016/0960-7404(94)90024-8

PMID:8186871

Abstract

The number of nucleolar organizer region proteins (NORs) identified by silver staining (Ag) was studied in 106 primary breast carcinomas. The AgNOR score (mean +/- SD) in tumours smaller than 2 cm was significantly lower than that in tumours larger than 2 cm (P < 0.05). However, there was no significant difference according to other clinicopathological characteristics. According to postoperative distant recurrence, the AgNOR count was significantly higher in the group with recurrence than in the group without recurrence (P < 0.05). Further, the survival rate was significantly lower in the high AgNOR score (> or = 3) group than in the low score (< 3) group (P < 0.01). The present study indicates that the AgNOR score in human breast cancer cells is useful for evaluating cell proliferative activity and may help predict postoperative distant recurrence and, ultimately, the postoperative prognosis of patients.

摘要

对106例原发性乳腺癌进行研究，通过银染（Ag）鉴定核仁组织区蛋白（NORs）的数量。小于2cm的肿瘤中AgNOR评分（均值±标准差）显著低于大于2cm的肿瘤（P<0.05）。然而，根据其他临床病理特征无显著差异。根据术后远处复发情况，复发组的AgNOR计数显著高于未复发组（P<0.05）。此外，AgNOR高评分（≥3）组的生存率显著低于低评分（<3）组（P<0.01）。本研究表明，人乳腺癌细胞中的AgNOR评分有助于评估细胞增殖活性，并可能有助于预测术后远处复发以及最终患者的术后预后。