注射至自发性高血压大鼠下丘脑室旁核的前列腺素E2对棕色脂肪组织产热的影响。

The effects of prostaglandin E2 injected into the paraventricular nucleus of the hypothalamus on brown adipose tissue thermogenesis in spontaneously hypertensive rats.

作者信息

Bhatnagar S, Meaney M J, Amir S

机构信息

Douglas Hospital Research Center, Department of Neurology, McGill University, Montreal, Que., Canada.

出版信息

Brain Res. 1993 Jun 11;613(2):285-7. doi: 10.1016/0006-8993(93)90911-6.

DOI:10.1016/0006-8993(93)90911-6

PMID:8186977

Abstract

We examined brown adipose tissue (BAT) thermogenic responses to prostaglandin E2 (PGE2) injected into the paraventricular nucleus of the hypothalamus in the spontaneously hypertensive rat (SHR). 250 ng of PGE2 produced smaller increases in BAT and core temperatures in SHRs compared to their normotensive controls, the WKYs. The results of the present study suggest that the ability of SHRs to mount a febrile response may be compromised.

摘要

我们研究了自发性高血压大鼠（SHR）下丘脑室旁核注射前列腺素E2（PGE2）后棕色脂肪组织（BAT）的产热反应。与正常血压对照大鼠WKY相比，250 ng的PGE2使SHR的BAT和核心体温升高幅度较小。本研究结果表明，SHR产生发热反应的能力可能受损。