卡巴胆碱和纳洛酮协同提高大鼠纹状体中的多巴胺释放：一项体内微透析研究。
Carbachol and naloxone synergistically elevate dopamine release in rat striatum: an in vivo microdialysis study.
作者信息
Kischka U, Farber S A, Marshall D, Wurtman R J
机构信息
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
出版信息
Brain Res. 1993 Jun 11;613(2):288-90. doi: 10.1016/0006-8993(93)90912-7.
Striatal dopamine (DA) release increased to 184% of baseline after 10-20 min of continuous intrastriatal perfusion with 10 mM carbachol, dropping to 124% after 30-40 min. The addition of 100 microM naloxone amplified (to 236% of baseline) and prolonged the increase in DA release, but naloxone alone (up to 1 mM) had no effect. These data suggest that activation of opiate-releasing striatal neurons suppresses cholinergic stimulation of DA release.
在用10 mM卡巴胆碱持续纹状体内灌注10 - 20分钟后，纹状体多巴胺（DA）释放增加至基线的184%，在30 - 40分钟后降至124%。添加100 microM纳洛酮可放大（至基线的236%）并延长DA释放的增加，但单独使用纳洛酮（高达1 mM）没有效果。这些数据表明，释放阿片类物质的纹状体神经元的激活抑制了胆碱能对DA释放的刺激。
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