二乙基亚硝胺在实验性诱导的大鼠肝硬化中致癌作用减弱：是延迟还是抑制？

Decreased hepatocarcinogenic effect of diethylnitrosamine in experimentally induced liver cirrhosis in rat: delay or inhibition?

作者信息

Zalatnai A, Lapis K

机构信息

1st Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, Budapest, Hungary.

出版信息

Cancer Lett. 1994 Apr 29;79(1):1-7. doi: 10.1016/0304-3835(94)90055-8.

DOI:10.1016/0304-3835(94)90055-8

PMID:8187048

Abstract

The relationship between CCl4 or (CCl4 + phenobarbital)-induced liver cirrhosis and diethylnitrosamine (DEN) hepatocarcinogenesis in male F-344 rats was investigated. DEN given alone produced no liver lesions after 16 weeks, but 4/12 (33%) neoplastic nodules developed when nitrosamine was administered to rats with previously established cirrhosis. On the other hand, (CCl4 + phenobarbital) post-treatment had an even stronger effect, increasing the yield of neoplastic nodules to 100% (28/28). Since the exposure time of DEN was the same in all treated groups (4 months), the results indicate the decreased effectiveness of (CCl4 + phenobarbital) pretreatment on DEN hepatocarcinogenesis.

摘要

研究了四氯化碳或（四氯化碳+苯巴比妥）诱导的雄性F-344大鼠肝硬化与二乙基亚硝胺（DEN）肝癌发生之间的关系。单独给予DEN 16周后未产生肝脏病变，但当将亚硝胺给予先前已建立肝硬化的大鼠时，有4/12（33%）的大鼠出现了肿瘤结节。另一方面，（四氯化碳+苯巴比妥）的后续处理效果更强，使肿瘤结节的发生率提高到100%（28/28）。由于所有处理组中DEN的暴露时间相同（4个月），结果表明（四氯化碳+苯巴比妥）预处理对DEN肝癌发生的有效性降低。