Jürgens G, Költringer P
Institute of Medical Biochemistry, Karl-Franzens Universität Graz, Austria.
Chem Phys Lipids. 1994 Jan;67-68:429-34. doi: 10.1016/0009-3084(94)90166-x.
Lp(a) was found to represent an independent risk factor of extracranial carotid atherosclerosis (CA). Here we report on an investigation with 808 subjects randomly selected from stroke patients as well as from asymptomatic subjects. Serum levels of Lp(a), total cholesterol (TC), HDL-C and the ratios of TC/HDL-C and LDL-C/HDL-C correlated highly significantly with the carotid score using a univariate test. Performing a discriminant analysis, the following ranking was obtained: Lp(a), HDL-C, LDL-C/HDL-C. Evaluation of the vessel wall elasticity in 746 subjects revealed Lp(a) to be the only highly significant parameter. Thus, Lp(a) has to be taken into consideration when establishing a risk profile of CA.
脂蛋白(a)被发现是颅外颈动脉粥样硬化（CA）的一个独立危险因素。在此，我们报告一项对808名受试者的调查，这些受试者是从卒中患者以及无症状受试者中随机选取的。采用单变量检验，脂蛋白(a)、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）以及TC/HDL-C和低密度脂蛋白胆固醇/高密度脂蛋白胆固醇的比值与颈动脉评分高度显著相关。进行判别分析后，得到以下排序：脂蛋白(a)、HDL-C、LDL-C/HDL-C。对746名受试者的血管壁弹性进行评估显示，脂蛋白(a)是唯一具有高度显著性的参数。因此，在建立CA风险概况时必须考虑脂蛋白(a)。
