Krausz Y, Shibley N, De Jong R B, Yaffe S, Glaser B
Department of Nuclear Medicine, Hadassah University Hospital, Jerusalem, Israel.
Clin Nucl Med. 1994 Feb;19(2):133-5. doi: 10.1097/00003072-199402000-00011.
In-111 DTPA octreotide, a labeled somatostatin analog, was reported to be superior to I-123 octreotide for detection of somatostatin-receptor-bearing tumors because of longer half-life and better labeling characteristics. In addition, renal rather than hepatobiliary clearance decreases intestinal interference and greatly reduces accumulation of the tracer in the gallbladder. Using the In-111 labeled octreotide, the authors noted distinct gallbladder visualization in one patient with an insulinoma who was studied following an overnight fast. In two additional patients scanned in the fasting state gallbladder uptake was also demonstrated. In all 3 patients, this uptake disappeared following a meal. The authors conclude that when using this imaging modality, abdominal scans should not be performed in the fasting state. Furthermore, if significant uptake is demonstrated in the gallbladder area, imaging should be repeated several hours later, following a fatty meal. Both false-positive and false-negative findings of pathologic uptake in this area will thus be avoided.
铟 - 111 二乙三胺五醋酸奥曲肽，一种标记的生长抑素类似物，据报道由于其半衰期更长且标记特性更好，在检测生长抑素受体阳性肿瘤方面优于碘 - 123 奥曲肽。此外，经肾脏而非肝胆清除可减少肠道干扰，并大大降低示踪剂在胆囊中的蓄积。使用铟 - 111 标记的奥曲肽，作者注意到一名胰岛素瘤患者在禁食过夜后进行研究时胆囊有明显显影。另外两名在禁食状态下扫描的患者也显示有胆囊摄取。在所有 3 名患者中，进食后这种摄取消失。作者得出结论，使用这种成像方式时，腹部扫描不应在禁食状态下进行。此外，如果在胆囊区域显示有明显摄取，应在进食高脂肪餐后数小时重复成像。这样可避免该区域病理性摄取的假阳性和假阴性结果。
