Shen Y C, Li G, Li Y T, Chen C H, Li S R, Zhao Y W, Zhang W X
Institute of Mental Health, Beijing Medical University.
Chin Med J (Engl). 1994 Jan;107(1):60-4.
The results of these epidemiological studies suggest that the morbidity of age related moderate and severe dementia among the population of 65+ was 1.82%, when adjusted by 1984 US population ratio, it became 3.2%, as reported by US and European authors. Yet MID appears more common than PDD, which was more close to the data from Japan. The average annual incidence of moderate and severe dementia for persons aged 60+ was 0.3% (95% CI: 0.08%-0.52%). The incidence for those aged 70-79 (0.41%) was similar to that reported by US authors (Sluss), 0.58% among 70-74 years old, but lower than that observed by European authors (Hagnell, Magnusso) varied from 1.2% to 5.2% in the same age group. These great differences are likely to be partly due to differences in the age structure of samples, instruments for testing dementia, and diagnostic criteria. The course and outcome of dementia after 3-year follow-up indicated that the average survival time was 8 years, and the risk for death of dementia was 3 times higher than that of the whole cohort; the results were similar to those reported by westerners. The major risk factors for AD as identified in this study showed that family history both in first degree relatives of AD and psychosis were significantly associated with AD. The finding was consistent with the genetic hypothesis in western countries. In 7 risk factors that have been studied in US and European countries, 6 showed that the family history of dementia was significantly associated with AD.(ABSTRACT TRUNCATED AT 250 WORDS)
这些流行病学研究结果表明，65岁及以上人群中与年龄相关的中度和重度痴呆症发病率为1.82%，按照1984年美国人口比例进行调整后，该发病率变为3.2%，这是美国和欧洲作者所报告的。然而，血管性痴呆似乎比帕金森病性痴呆更常见，这与日本的数据更为接近。60岁及以上人群中度和重度痴呆症的平均年发病率为0.3%（95%置信区间：0.08%-0.52%）。70-79岁人群的发病率（0.41%）与美国作者（斯拉斯）报告的相似，70-74岁人群的发病率为0.58%，但低于欧洲作者（哈内尔、马格努索）观察到的发病率，同一年龄组的发病率在1.2%至5.2%之间变化。这些巨大差异可能部分归因于样本年龄结构、痴呆症检测工具和诊断标准的不同。3年随访后痴呆症的病程和结局表明，平均生存时间为8年，痴呆症患者的死亡风险比整个队列高3倍；结果与西方人报告的相似。本研究确定的阿尔茨海默病主要危险因素表明，阿尔茨海默病和精神病的一级亲属家族史均与阿尔茨海默病显著相关。这一发现与西方国家的遗传假说一致。在美国和欧洲国家研究的7个危险因素中，有6个表明痴呆症家族史与阿尔茨海默病显著相关。（摘要截选至250字）
