[Mapping of DNAse I hypersensitive sites in the 5'-terminal region of the chicken alpha-globin gene domain].

The distribution of DNaseI-hypersensitive sites in the region upstream of the chicken alpha-globin genes domain was studied. Two clusters of sites covering regions from 14.3 to 11.7 and from 5.3 to 2.4 kb 5' of the p gene were localized. Each cluster includes both erythroid-specific and constitutive DNaseI-hypersensitive sites. The discovery of erythroid-specific DNaseI-hypersensitive sites inside the first of mentioned clusters demonstrates that neither block of AT-rich sequences nor matrix attachment sites, which were found 4 and 8 kb upstream of the p gene, represent the border of the alpha-globin gene domain.