Razin S V
Genetika. 1994 Jan;30(1):33-6.
The distribution of DNaseI-hypersensitive sites in the region upstream of the chicken alpha-globin genes domain was studied. Two clusters of sites covering regions from 14.3 to 11.7 and from 5.3 to 2.4 kb 5' of the p gene were localized. Each cluster includes both erythroid-specific and constitutive DNaseI-hypersensitive sites. The discovery of erythroid-specific DNaseI-hypersensitive sites inside the first of mentioned clusters demonstrates that neither block of AT-rich sequences nor matrix attachment sites, which were found 4 and 8 kb upstream of the p gene, represent the border of the alpha-globin gene domain.
研究了鸡α-珠蛋白基因结构域上游区域中脱氧核糖核酸酶I超敏位点的分布。定位了两个超敏位点簇，分别覆盖p基因5'端上游14.3至11.7 kb以及5.3至2.4 kb的区域。每个簇都包含红系特异性和组成型脱氧核糖核酸酶I超敏位点。在上述第一个簇内发现红系特异性脱氧核糖核酸酶I超敏位点，这表明在p基因上游4 kb和8 kb处发现的富含AT的序列块或基质附着位点都不代表α-珠蛋白基因结构域的边界。
