野生小家鼠品系（西班牙小鼠）中缺乏类固醇15α-羟化酶基因（Cyp2a-4）：细胞色素P450基因超家族的快速进化

Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.

作者信息

Aida K, Moore R, Negishi M

机构信息

Pharmacogenetics Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709.

出版信息

Genomics. 1994 Feb;19(3):564-6. doi: 10.1006/geno.1994.1107.

DOI:10.1006/geno.1994.1107

PMID:8188299

Abstract

Steroid 15 alpha-hydroxylase P450(15 alpha) and coumarin 7-hydroxylase P450coh genes Cyp2a-4 and Cyp2a-5 are members of the mouse P450 2A subfamily. Whereas Mus musclus domesticus strains contain both genes, wild mouse strain Mus spretus contains only Cyp2a-5. Evolutionarily, therefore, Cyp2a-5 is ancestral to Cyp2a-4. Moreover, the line to Cyp2a-4 descended as recently as 3 million years ago in an ancestral mouse. This evidence implies a rapid evolution of the P450 gene superfamily.

摘要

类固醇15α-羟化酶细胞色素P450（15α）和香豆素7-羟化酶细胞色素P450coh基因Cyp2a - 4和Cyp2a - 5是小鼠细胞色素P450 2A亚家族的成员。小家鼠品系同时含有这两个基因，而野生小鼠品系西班牙小鼠仅含有Cyp2a - 5。因此，从进化角度来看，Cyp2a - 5是Cyp2a - 4的祖先。此外，Cyp2a - 4这条谱系在距今仅300万年前的一个祖先小鼠中才分化出来。这一证据表明细胞色素P450基因超家族经历了快速进化。