Rolston D D, Raghupathy P, Cutting W A
Department of Gastroenterology, Christian Medical College and Hospital, Vellore, India.
J Diarrhoeal Dis Res. 1993 Dec;11(4):217-21.
The effects of a maltodextrin (dextrose equivalent 12)-electrolyte solution and a maltodextrin-electrolyte solution with added nutrients on net water and electrolyte transport in the secreting rat intestine was compared with the citrate-World Health Organization oral rehydration solution to determine the need for a clinical trial to evaluate the efficacy of these maltodextrin solutions in acute diarrhoea treatment. Cholera toxin consistently produced net water secretion (-36.5 +/- 9.9 mean +/- SEM microliter/min/g dry weight of intestine). All three solutions reversed the cholera toxin-induced net intestinal water secretion to net absorption. Significantly greater net water absorption occurred from the maltodextrin-electrolyte solution compared to the World Health Organization solution (P < 0.05) but not when compared to the maltodextrin-electrolyte-nutrient solution. Net sodium, potassium and chloride fluxes due to the World Health Organization-solution were not significantly different from the maltodextrin-electrolyte solution. These data provide a rationale for initiating a clinical trial.
将麦芽糊精（葡萄糖当量为12）-电解质溶液以及添加了营养成分的麦芽糊精-电解质溶液对分泌期大鼠肠道中水和电解质净转运的影响，与柠檬酸盐-世界卫生组织口服补液溶液进行比较，以确定是否有必要开展一项临床试验来评估这些麦芽糊精溶液在治疗急性腹泻方面的疗效。霍乱毒素始终会引起净水分泌（平均为-36.5±9.9微升/分钟/克肠道干重，标准误）。所有三种溶液都能将霍乱毒素诱导的肠道净水分泌逆转成净吸收。与世界卫生组织溶液相比，麦芽糊精-电解质溶液产生的净水吸收显著更多（P<0.05），但与麦芽糊精-电解质-营养溶液相比则无显著差异。世界卫生组织溶液引起的钠、钾和氯的净通量与麦芽糊精-电解质溶液无显著差异。这些数据为启动一项临床试验提供了依据。
