Yusa T, Tamiya N, Yamaguchi Y, Takeda T, Ogawa T, Kimura H, Fujimura S
Department of Surgery, Chiba Rosai Hospital.
Nihon Kyobu Shikkan Gakkai Zasshi. 1994 Mar;32(3):211-5.
In order to investigate the usefulness of thymidine kinase, which acts to salvage thymidine to its nucleotide for DNA biosynthesis, as a marker of malignancy in lung cancer, the enzyme activities in extracts of tumors and uninvolved lungs of 83 resected cases of lung cancer were determined. The mean value of thymidine kinase activity in tumors was as much as 4.3 times higher than that of uninvolved lungs. There was no significant correlation between the activity in tumors and clinicopathological findings such as histological type, the grade of histological differentiation, pT factor, pN factor, pTNM stage and tumor size. The tumor doubling time did, however, show a significant inverse correlation with activity when compared logarithmically (r = 0.879, p = 0.00002). Moreover, there was a significant relationship between enzyme activity and post-operative recurrence of lung cancer. In conclusion, thymidine kinase was found to be a useful marker of malignancy in lung cancer.
为了研究胸苷激酶作为肺癌恶性肿瘤标志物的作用，胸苷激酶可将胸苷挽救为其核苷酸用于DNA生物合成，我们测定了83例手术切除的肺癌病例的肿瘤组织及未受累肺组织提取物中的酶活性。肿瘤组织中胸苷激酶活性的平均值比未受累肺组织高4.3倍。肿瘤组织中的活性与组织学类型、组织学分化程度、pT因子、pN因子、pTNM分期和肿瘤大小等临床病理特征之间无显著相关性。然而，当对肿瘤倍增时间进行对数比较时，其与活性呈显著负相关（r = 0.879，p = 0.00002）。此外，酶活性与肺癌术后复发之间存在显著关系。总之，胸苷激酶被发现是肺癌恶性肿瘤的一个有用标志物。
