Carrillo M C, Ivy G O, Milgram N W, Head E, Wu P, Kitani K
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.
Life Sci. 1994;54(20):1483-9. doi: 10.1016/0024-3205(94)90015-9.
Seven beagle dogs were administered sucrose (control animals) or different doses of (-)deprenyl orally by means of capsules for 3 weeks. Activities of Cu Zn-SOD and Mn-SOD were determined in striatum and hippocampus in these animals. There was a significant dose-dependent increase in activities of total as well as in both types of SOD enzymes in striatum but not in hippocampus. The results suggest that this monoamine oxidase B inhibitor can increase antioxidant enzyme activities in striatum but not in hippocampus in the dog, thus showing brain region selectivity. These results are in accordance with previously published observations in rats.
七只比格犬通过胶囊口服蔗糖（对照动物）或不同剂量的（-）司来吉兰，持续3周。测定了这些动物纹状体和海马体中铜锌超氧化物歧化酶（Cu Zn-SOD）和锰超氧化物歧化酶（Mn-SOD）的活性。纹状体中总超氧化物歧化酶以及两种类型超氧化物歧化酶的活性均有显著的剂量依赖性增加，但海马体中没有。结果表明，这种单胺氧化酶B抑制剂可增加犬纹状体而非海马体中的抗氧化酶活性，从而显示出脑区选择性。这些结果与先前在大鼠中发表的观察结果一致。
