Yoshida F, Matsuo S, Fujishima H, Kim H K, Tomita T
Third Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Nephron. 1994;66(3):317-25. doi: 10.1159/000187830.
The strain of FGS/Nga mouse is reported to develop proteinuria and progressive glomerulosclerosis. We studied the renal pathology of that strain periodically for 1 year. Focal and segmental glomerulosclerosis was observed 3 months after birth and the lesion progressed to the glomerular obsolescence in a year. Electron microscopic study revealed electron dense deposits (DD) in the mesangium and the splitting of glomerular basement membrane. Studies using immunofluorescence and immunoelectron microscopy revealed that these DD were contained IgA, IgM, C3 and the retroviral envelope antigen (gp70). Clinically, proteinuria began at the age of 3 months and the renal function was decreased on time course. No other organs were involved. We studied the renal lesions of FGS mice by the histological and immunohistochemical methods and concluded that this mouse strain provides the tool for studying the mechanisms of the progression of glomerulosclerosis.
据报道，FGS/Nga小鼠品系会出现蛋白尿和进行性肾小球硬化。我们对该品系小鼠的肾脏病理进行了为期1年的定期研究。出生3个月后观察到局灶节段性肾小球硬化，病变在1年内进展为肾小球荒废。电子显微镜研究显示系膜中有电子致密沉积物（DD）以及肾小球基底膜分裂。免疫荧光和免疫电子显微镜研究表明，这些DD含有IgA、IgM、C3和逆转录病毒包膜抗原（gp70）。临床上，蛋白尿在3个月龄时开始出现，且肾功能随时间推移而下降。没有其他器官受累。我们通过组织学和免疫组织化学方法研究了FGS小鼠的肾脏病变，得出结论：该小鼠品系为研究肾小球硬化进展机制提供了工具。
