Ausinsch B, Malagodi M H, Munson E S
Br J Anaesth. 1976 Apr;48(4):309-13. doi: 10.1093/bja/48.4.309.
Diazepam 0.05-0.25 mg/kg increased the dose of lignocaine required to cause seizures in Rhesus monkeys by 24-34%. Spontaneous ventilation was maintained adequately during lignocaine administration following diazepam treatment and no adverse cardiovascular effects occurred. Before the onset of lignocaine-induced seizures in non-treated animals, the animals appeared to be drowsy. However, prior to administration of diazepam masked this effect. Convulsions were controlled by smaller doses of diazepam in non-treated animals than in diazepam-treated animals. Also, the animals that were pretreated with diazepam had a greater duration of depression after seizure.
地西泮0.05 - 0.25毫克/千克可使恒河猴诱发癫痫所需的利多卡因剂量增加24% - 34%。地西泮治疗后给予利多卡因期间，自主呼吸维持良好，未出现不良心血管效应。在未治疗的动物中，利多卡因诱发癫痫发作前，动物似乎会出现嗜睡。然而，给予地西泮可掩盖这种效应。与地西泮治疗的动物相比，未治疗的动物用较小剂量的地西泮即可控制惊厥。此外，用地西泮预处理的动物在癫痫发作后抑郁持续时间更长。
