Rodriguez M, Santana C, Afonso D
Department of Physiology, School of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain.
Physiol Behav. 1994 Apr;55(4):607-13. doi: 10.1016/0031-9384(94)90033-7.
It was previously reported that oral administration of tyrosine (500 mg/kg) to pregnant rats increases tyrosine and monoamines level in the fetal brain and modifies locomotion during postnatal life. In the present study, it was found that this treatment alters behavioral lateralization in the offspring. Neonatal rats whose mothers received tyrosine during the second half of gestation showed a low level of absolute and population laterality in both tail and head movements. The alteration of behavioral lateralization was also found during postnatal development and during adulthood. The T-maze behavioral ontogeny was different for tyrosine-mother and sham-treated or untreated mother rats. During adulthood, the T-max lateralization after stress sessions (a procedure that decreases alternation behavior and facilitates the quantification of behavioral lateralization) was also different in control and tyrosine-mother groups. Neonatal and adult rats showed an increase in right-side movements probability. These data provide evidence that maternal ingestion of a catecholamine precursor during gestation may induce a long-lasting modification of the behavioral lateralization of the offspring.
先前有报道称，给怀孕大鼠口服酪氨酸（500毫克/千克）会增加胎鼠大脑中的酪氨酸和单胺水平，并改变其出生后的运动行为。在本研究中，发现这种处理会改变后代的行为偏侧化。在妊娠后半期其母亲接受酪氨酸处理的新生大鼠，在尾巴和头部运动中表现出较低的绝对和群体偏侧化水平。在出生后发育期间和成年期也发现了行为偏侧化的改变。酪氨酸处理组母鼠与假处理或未处理母鼠的后代在T迷宫行为个体发育方面存在差异。在成年期，应激实验（一种会降低交替行为并便于量化行为偏侧化的程序）后的T迷宫偏侧化在对照组和酪氨酸处理组母鼠的后代中也有所不同。新生大鼠和成年大鼠右侧运动的概率增加。这些数据表明，孕期母体摄入儿茶酚胺前体可能会对后代的行为偏侧化产生长期影响。
