[The gastrin and pepsinogen levels of patients with chronic atrophic gastritis and duodenal ulcer].

The radioimmunological method was used to examine the content of blood plasma gastrin and pepsinogen in the blood plasma and bioptate of gastric mucosa in 22 patients with duodenal ulcer and 20 patients with chronic atrophic gastritis. Patients with atrophic antral gastritis show a reduction of the blood gastrin level while the pepsinogen level remained unchanged. In atrophic fundal gastritis the gastrin content rose while the pepsinogen level dropped. There was a clear increase of the pepsinogen level both in the blood plasma and bioptate of the gastric mucosa. The obtained data are of diagnostic significance in duodenal ulcer and chronic gastritis.