甲状腺功能亢进和甲状腺功能减退对促甲状腺激素释放激素诱导的大鼠生长激素释放的影响。

Effects of hyperthyroidism and hypothyroidism on rat growth hormone release induced by thyrotropin-releasing hormone.

作者信息

Chihara K, Kato Y, Ohgo S, Iwasaki Y, Maeda K

出版信息

Endocrinology. 1976 Jun;98(6):1396-400. doi: 10.1210/endo-98-6-1396.

PMID:819251

Abstract

The effect of synthetic thyrotropin-releasing hormone (TRH) on the release of growth hormone (GH) and thyroid-stimulating hormone (TSH) was investigated in euthyroid, hypothyroid, and hyperthyroid rats under urethane anesthesia. In euthyroid control rats, intravenous injection of TRH (200 ng/100 g BW) resulted in a significant increase in both plasma GH and TSH. In rats made hypothyroid by treatment with propylthiouracil or by thyroidectomy, basal GH and TSH levels were significantly elevated with exaggerated responses to TRH. In contrast, plasma GH and TSH responses to TRH were both significantly inhibited in rats made hyperthyroid by L-thyroxine (T4) treatment. These results suggest that altered thyroid status influences GH release as well as TSH secretion induced by TRH in rats.

摘要

在氨基甲酸乙酯麻醉下，研究了合成促甲状腺激素释放激素（TRH）对正常甲状腺、甲状腺功能减退和甲状腺功能亢进大鼠生长激素（GH）和促甲状腺激素（TSH）释放的影响。在正常甲状腺对照大鼠中，静脉注射TRH（200 ng/100 g体重）导致血浆GH和TSH均显著增加。在用丙硫氧嘧啶治疗或甲状腺切除术后造成甲状腺功能减退的大鼠中，基础GH和TSH水平显著升高，对TRH的反应增强。相反，在经L-甲状腺素（T4）治疗造成甲状腺功能亢进的大鼠中，血浆GH和TSH对TRH的反应均显著受到抑制。这些结果表明，甲状腺状态的改变会影响大鼠中TRH诱导的GH释放以及TSH分泌。