Wen H, Zhang H W, Muhmut M, Zou P F, New R R, Craig P S
Department of Surgery and Pharmaceutics, Xinjiang Medical College, China.
Ann Trop Med Parasitol. 1994 Feb;88(1):49-52. doi: 10.1080/00034983.1994.11812834.
Concentrations of albendazole were measured, by high-pressure liquid chromatography, in 19 patients being treated for cystic echinococcosis. All of the patients were given three 4-week courses of albendazole (20 mg/kg/day), separated by 10-day-long drug-free intervals. Seven patients also received three courses of cimetidine (10 mg/kg/day). Concentrations of albendazole sulphoxide (ABZSX) were significantly higher in samples of bile and hydatid cyst fluid from the patients receiving albendazole and cimetidine than in those from patients receiving albendazole alone (P < 0.05). The therapeutic benefit of the combined drug treatment, which was well-tolerated, was more than that with albendazole alone.
采用高压液相色谱法测定了19例接受阿苯达唑治疗的囊性棘球蚴病患者体内阿苯达唑的浓度。所有患者均接受三个为期4周的阿苯达唑疗程（20 mg/kg/天），疗程之间间隔10天无药期。7例患者还接受了三个疗程的西咪替丁（10 mg/kg/天）治疗。接受阿苯达唑和西咪替丁联合治疗的患者，其胆汁和棘球蚴囊液样本中阿苯达唑亚砜（ABZSX）的浓度显著高于仅接受阿苯达唑治疗的患者（P < 0.05）。联合药物治疗耐受性良好，其治疗效果优于单独使用阿苯达唑。
