[Electronmicroscopic studies of the island of Langerhans of the rat pancreas after oral application of glibenclamide].
作者信息
Galabova R, Hahn H J, Petkov P
出版信息
Endokrinologie. 1975 Nov;66(2):211-7.
PMID:819258
Abstract
The morphological alterations of B-cells of pancreatic islets from rats were investigated 2, 8 and 24 h after a peroral application of glibenclamide. All cell organelles showed signs of activation, as enlargement of the rough endoplasmatic reticulum and the Golgi apparatus, increased number of mitochondriae and degranulation. These changes could be observed partly 2 h after glibenclamide, but the drastical alterations were found 24 h after application of the sulfonylurea.
摘要
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