HLA - B5抗原与白塞病特定表现的关联。

The association of HLA-B5 antigen with specific manifestations of Behçet's disease.

作者信息

Azizleri G, Aksungur V L, Sarica R, Akyol E, Ovül C

机构信息

Department of Dermatology, Istanbul Medical Faculty, Turkey.

出版信息

Dermatology. 1994;188(4):293-5. doi: 10.1159/000247169.

DOI:10.1159/000247169

PMID:8193403

Abstract

The HLA-B5 phenotype was investigated in 235 patients with Behçet's disease and in 100 healthy persons. HLA-B5 was more frequent in the patients (77 vs. 30% p < 0.001, relative risk = 7.8). The frequency of HLA-B5 was higher in patients with genital ulceration than without (82.3 vs. 63%, p < 0.01). Patients with thrombophlebitis showed a less frequent positivity of HLA-B5 antigen than the patients without thrombophlebitis (50 vs. 79.2%, p < 0.02). These results suggest that HLA-B5-related genes not only affect the development of Behçet's disease but also the occurrence of its clinical manifestations.

摘要

对235例白塞病患者和100名健康人进行了HLA - B5表型研究。HLA - B5在患者中更为常见（77% 对30%，p < 0.001，相对风险 = 7.8）。有生殖器溃疡的患者中HLA - B5的频率高于无生殖器溃疡的患者（82.3% 对63%，p < 0.01）。有血栓性静脉炎的患者HLA - B5抗原阳性率低于无血栓性静脉炎的患者（50% 对79.2%，p < 0.02）。这些结果表明，与HLA - B5相关的基因不仅影响白塞病的发生，还影响其临床表现的出现。