白塞病：临床表现与人类白细胞抗原（HLA）抗原之间缺乏相关性。

Behçet's disease: lack of correlation of clinical manifestations with HLA antigens.

作者信息

Müftüoğlu A U, Yazici H, Yurdakul S, Pazarli H, Ozyazgan Y, Tüzün Y, Altaç M, Yalçin B

出版信息

Tissue Antigens. 1981 Feb;17(2):226-30. doi: 10.1111/j.1399-0039.1981.tb00687.x.

DOI:10.1111/j.1399-0039.1981.tb00687.x

Abstract

It has been suggested that certain tissue types are associated with different clinical manifestations of Behçet's disease in Japan and England. Regional differences in the associations between HLA antigens and Behçet's disease have been established. We tissue type 119 patients with Behçet's disease in Istanbul and attempted to correlate various clinical manifestations with HLA antigens. The frequency of only one tissue antigen, HLA-B5, was found to be increased in these series. HLA-B5 was present in 94 of 119 patients (77%) compared to 89 of 268 controls (33%), P less than 0.0001, ARR = 6.79. Age of onset, sex, incidences of ocular disease, arthritis, thrombophlebitis and erythema nodosum did not show any positive or negative associations with any of the alleles tested.

摘要

有研究表明，在日本和英国，某些组织类型与白塞病的不同临床表现相关。HLA抗原与白塞病之间的关联存在地区差异。我们对伊斯坦布尔的119例白塞病患者进行了组织分型，并试图将各种临床表现与HLA抗原进行关联。在这些病例系列中，仅发现一种组织抗原HLA - B5的频率有所增加。119例患者中有94例（77%）存在HLA - B5，而268例对照中有89例（33%）存在，P小于0.0001，归因风险比（ARR）= 6.79。发病年龄、性别、眼部疾病、关节炎、血栓性静脉炎和结节性红斑的发病率与所检测的任何等位基因均未显示出正相关或负相关。