Muntean W, Zenz W, Finding K, Zobel G, Beitzke A
Department of Pediatrics, University of Graz, Austria.
Acta Paediatr. 1994 Jan;83(1):84-7. doi: 10.1111/j.1651-2227.1994.tb12958.x.
A two-year-old infant developed an inhibitor to factor V after cardiac surgery, with application of fibrin sealant containing bovine thrombin. Investigation of this inhibitor by means of inhibition experiments and immunoblot analysis revealed that the inhibitor reacted strongly with bovine, but only weakly with human factor V. Plasmapheresis proved effective in increasing factor V levels. This patient provides further evidence that exposure to topical thrombin preparations may lead to the development of inhibitors in the postoperative period that may cause bleeding complications.
一名两岁婴儿在心脏手术后出现了针对凝血因子V的抑制剂，当时使用了含牛凝血酶的纤维蛋白密封剂。通过抑制实验和免疫印迹分析对该抑制剂进行研究发现，该抑制剂与牛凝血因子V反应强烈，但与人类凝血因子V反应较弱。血浆置换被证明对提高凝血因子V水平有效。该患者进一步证明，接触局部凝血酶制剂可能导致术后出现抑制剂，进而引发出血并发症。
