一名因产生类促肾上腺皮质激素释放因子而患肺鳞状细胞癌的患者出现异位库欣综合征。

Ectopic Cushing's syndrome in a patient with squamous cell carcinoma of the lung due to CRF-like production.

作者信息

Boon E S, Leers M P, Tjwa M K

机构信息

Dept of Respiratory Medicine, De Wever Hospital, Heerlen, The Netherlands.

出版信息

Monaldi Arch Chest Dis. 1994 Feb;49(1):19-21.

PMID:8193614

Abstract

We present a patient with a poorly differentiated squamous cell carcinoma of the left lower lobe, who developed Cushing's syndrome. Adrenocorticotrophic hormone (ACTH) and cortisol levels in the blood were extremely elevated, but immunostaining for ACTH and corticotrophin releasing factor (CRF) of the primary tumour and metastases was negative. The ectopic Cushing's syndrome was probably caused by CRF-like production.

摘要

我们报告一例左肺下叶低分化鳞状细胞癌患者，该患者出现了库欣综合征。血液中的促肾上腺皮质激素（ACTH）和皮质醇水平极度升高，但对原发性肿瘤及转移灶进行ACTH和促肾上腺皮质激素释放因子（CRF）免疫染色均为阴性。异位库欣综合征可能是由类CRF分泌所致。