Reeves B R, Kempski H, Jani K, Borrow J, Howe K, Solomon E, Kearney L, Cotter F
Leukaemia Research Fund Centre for Childhood Leukaemia, Institute of Child Health, London, U.K.
Cancer Genet Cytogenet. 1994 May;74(1):50-3. doi: 10.1016/0165-4608(94)90028-0.
A case of acute monocytic leukemia with t(11;17)(123;q11-21) arising in a 4-month-old boy is described. The breakpoint on chromosome 11 could be mapped to an 8-kb BamHI fragment within the MLL-1 gene, as seen in the majority of infant leukemias. In situ hybridization with cosmid probes allowed us to map the breakpoint on 17q proximal to the RARA gene, while Southern and Northern analyses showed that the gene was not disrupted by the translocation.
