微生物酶对头孢菌素对硝基苄酯的脱酯化作用。
De-esterification of cephalosporin para-nitrobenzyl esters by microbial enzymes.
作者信息
Brannon D R, Mabe J A, Fukuda D S
出版信息
J Antibiot (Tokyo). 1976 Feb;29(2):121-4. doi: 10.7164/antibiotics.29.121.
PMID:819407
Abstract
Bacteria and actinomycetes were screened for esterase enzymes capable of removing the para-nitrobenzyl ester from cephalosporins. An esterase preparation from Bacillus subtilis was used to prepare cephalexin and 7-ADCA from the corresponding para-nitrobenzyl esters.
摘要
筛选细菌和放线菌以寻找能够从头孢菌素中去除对硝基苄酯的酯酶。使用枯草芽孢杆菌的一种酯酶制剂从相应的对硝基苄酯制备头孢氨苄和7-氨基去乙酰氧基头孢烷酸。
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