Bondareva N S, Levitov M M
Mikrobiologiia. 1980 Nov-Dec;49(6):870-5.
Bacteria and actinomycetes were screened for finding organisms that produced enzymes transforming cephalosporin C. Different bacteria were found to be capable for producing enzymes that degraded cephalosporin; actinomycetes possessed this capability to a lesser extent. The transformation of cephalosporin was catalyzed by beta-lactamase and acetyl esterase. One and the same culture could synthesize the both enzymes simultaneously; their activities and proportion depend on the conditions of cultivation. The production of enzymes degrading cephalosporin in bacteria seems to be a trait typical of a species or a strain.
筛选细菌和放线菌以寻找能够产生转化头孢菌素C的酶的生物体。发现不同的细菌能够产生降解头孢菌素的酶；放线菌在较小程度上具有这种能力。头孢菌素的转化由β-内酰胺酶和乙酰酯酶催化。同一培养物可以同时合成这两种酶；它们的活性和比例取决于培养条件。细菌中降解头孢菌素的酶的产生似乎是一个物种或菌株的典型特征。
