Geddes R, Chow J C
Biochemistry SBS, University of Auckland, New Zealand.
Carbohydr Res. 1994 Mar 18;256(1):139-47. doi: 10.1016/0008-6215(94)84233-7.
The effect of a period of starvation followed by refeeding on skeletal muscle glycogen was investigated by the use of double-labelled radioactive glucose precursors in rats. Skeletal muscle glycogen, which is not depleted to anything like the extent of liver glycogen, shows a remarkable stability with respect to its overall molecular size distribution during starvation and subsequent refeeding. The experiments also indicate that there is a control mechanism in muscle tissue enabling the synthesis of lysosomal glycogen to be switched off during the initial part of the refeeding process. The results emphasise the inadequacy of the Cori cycle and a modified version is proposed.
通过在大鼠中使用双标记放射性葡萄糖前体，研究了饥饿一段时间后再喂食对骨骼肌糖原的影响。骨骼肌糖原不像肝糖原那样会被大量消耗，在饥饿和随后的再喂食过程中，其总体分子大小分布显示出显著的稳定性。实验还表明，肌肉组织中存在一种控制机制，能在再喂食过程的初始阶段关闭溶酶体糖原的合成。这些结果强调了科里循环的不足之处，并提出了一个改进版本。
