Smiles K A, Elizondo R S, Barney C C
J Appl Physiol. 1976 May;40(5):653-7. doi: 10.1152/jappl.1976.40.5.653.
A technique is presented for preparing a durable thermode implant in the hypothalamus of the rhesus monkey. In unanesthetized monkeys implanted with thermodes in the anterior hypothalamic area of the brain, a linear relation was found between local sweat rates on the general body surface and clamped hypothalamic temperature. Changes in skin temperature were found to shift the hypothalamic set-point temperature at which sweating began but did not alter the gain of the hypothalamic temperature-sweat rate relationship. This study provides direct support for the concept that central brain temperature and skin temperature interact additively in the control of sweating in higher primates. Due to the very close similarity between these responses and those seen with indirect measurements of brain temperature in men, the rhesus monkey is seen as an excellent experimental analogue for studying human thermoregulation.
本文介绍了一种在恒河猴下丘脑制备耐用热电极植入物的技术。在未麻醉的猴子大脑下丘脑前部区域植入热电极后，发现全身体表局部出汗率与钳制的下丘脑温度之间存在线性关系。发现皮肤温度的变化会改变出汗开始时的下丘脑设定点温度，但不会改变下丘脑温度-出汗率关系的增益。这项研究为高等灵长类动物出汗控制中脑中央温度和皮肤温度相加性相互作用的概念提供了直接支持。由于这些反应与在人类中通过间接测量脑温所观察到的反应非常相似，恒河猴被视为研究人类体温调节的极佳实验模型。
