[粉防己碱的临床心脏电生理效应]

[The clinical cardiac electrophysiologic effects of tetrandrine].

作者信息

Li W H

机构信息

Institute of Cardiovascular Diseases, Tong Ji Medical University, Wuhan.

出版信息

Zhonghua Xin Xue Guan Bing Za Zhi. 1993 Aug;21(4):225-6, 254.

PMID:8194436

Abstract

Acute electrophysiologic effects of intravenous tetrandrine were evaluated with programmed electrical stimulation in 20 patients. The results showed that: (1) tetrandrine significantly lengthened SCL and A-H interval (P < 0.001), AVNERP, AVNWCL and SPERP (P < 0.05). It did not affect the SACT, SNRT, P-A, H-V, Q-T intervals and the ERP of atrium, ventricle and accessory pathway significantly. Its electrophysiologic property is similar to verapamil. (2) It prevented induction of SVT in 4 cases, 4 cases of sustained SVT were no longer sustained, the effective rate is 85.7%. The curative effect on AVNRT (100%) is better than that on AVRT (71.4%). (3) No severe side effect was observed. Therefore, tetrandrine is an effective drug for the treatment of SVT.

摘要

采用程控电刺激技术对20例患者静脉注射粉防己碱的急性电生理效应进行了评估。结果显示：（1）粉防己碱可显著延长窦房结恢复时间（SCL）和A-H间期（P<0.001）、房室结有效不应期（AVNERP）、房室结功能不应期（AVNWCL）和旁道有效不应期（SPERP）（P<0.05）。对窦房传导时间（SACT）、窦房结恢复时间（SNRT）、P-A间期、H-V间期、Q-T间期以及心房、心室和旁道的有效不应期无明显影响。其电生理特性与维拉帕米相似。（2）预防4例室上性心动过速（SVT）的诱发，4例持续性SVT转为非持续性，有效率为85.7%。对房室结折返性心动过速（AVNRT）的疗效（100%）优于房室折返性心动过速（AVRT）（71.4%）。（3）未观察到严重副作用。因此，粉防己碱是治疗SVT的有效药物。